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KMID : 1007520150240031115
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Food Science and Biotechnology
2015 Volume.24 No. 3 p.1115 ~ p.1121
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Inhibition of the Lipogenesis in Liver and Adipose Tissue of Diet-induced Obese C57BL/6 Mice by Feeding Oleic Acid-rich Sesame Oil
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Pan Jeong-Hoon
Kim Mi-Jeong
Kim Jun-Ho
Cho Yun-Jeong
Shin Han-Seung
Sung Jung-Suk
Park Tae-Sik
Yoon Ho-Geun
Park Sung-jin
Kim Young-Jun
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Abstract
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The effects of sesame oil (SO) on lipogenic gene expression and lipid metabolism were observed. One percent of SO was added into the high-fat diet (HFD) used to feed C57BL/6 male mice for 8 weeks. SO significantly lowered adipose tissue mass than that of the high-fat control group. In addition, serum and hepatic lipid contents were markedly lower than those of the high-fat control group. Especially, the ratio of HDL/LDL was much higher than that of the HFD group. The gene expression of key lipogenic enzymes, Ppar-γ, Srebp-1c, Scd-1, Fas, Acc, Lpl, and malic enzyme, was significantly downregulated in the liver and adipose tissue of mice fed sesame oil. This study suggests that high proportion of oleic acid in SO might be strongly associated with lowering serum and hepatic lipid profile and suppressing lipogenic gene expression.
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KEYWORD
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sesame oil, lipid profile, lipogenic gene, obesity, oleic acid
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